Benadryl, known generically as diphenhydramine, is a common over-the-counter medication often considered for human use. While some veterinarians may recommend it for pets, including dogs, it’s crucial to approach its use with caution. This guide provides information on the appropriate dosage of children’s Benadryl for dogs, but always consult with your veterinarian before administering any medication to your pet.
You might consider using Benadryl for your dog to alleviate anxiety or to treat a mild allergic reaction, such as one from an insect sting. However, while generally well-tolerated by dogs, Benadryl isn’t always the ideal solution. In some cases, it can have the opposite effect, increasing anxiety. Furthermore, Benadryl is contraindicated for dogs with certain health conditions or those taking specific medications.
Therefore, understanding when Benadryl is safe and effective, and when alternative treatments are necessary, is paramount. Here are some essential considerations before administering Benadryl to your dog.
What is Benadryl?
Benadryl is a first-generation antihistamine that works by blocking H-1 receptors in the body, preventing them from reacting to histamine. It can also help reduce nausea and vomiting by inhibiting the chemoreceptor trigger zone (the brain’s vomiting center) and diminishing the vestibular apparatus’s response to motion.
Veterinarians commonly suggest Benadryl for dogs to prevent or treat mild allergic reactions and reduce nausea and vomiting associated with motion sickness or vestibular disease.
Can Benadryl Be Used for Dog Allergies?
Oral Benadryl can effectively alleviate mild allergic symptoms in dogs triggered by common allergens like pollen, mold, and house mites, especially when combined with other allergy treatments. It can also be used for mild reactions to insect bites or stings. Additionally, oral or injectable Benadryl can serve as a pre-treatment for mild allergic vaccine reactions.
However, for acute allergic reactions characterized by facial swelling or breathing difficulties, immediate veterinary attention is crucial. Severe allergic reactions can be life-threatening and often necessitate aggressive supportive care, including steroids and epinephrine, alongside Benadryl.
Can Dogs Take Benadryl for Anxiety?
While Benadryl is sometimes suggested for dogs with travel anxiety or those fearful of fireworks and thunderstorms, its effectiveness is limited. It might induce slight sleepiness and reduce responsiveness in some dogs but does little to address the root cause of their anxiety.
Benadryl is more effective in preventing motion sickness in dogs. If your dog’s anxiety stems from car-related nausea, it might offer some relief. However, some dogs and cats exhibit hyperactivity rather than sedation in response to Benadryl.
If your dog suffers from anxiety, consulting your veterinarian is essential to determine the best course of treatment, which might involve environmental modifications, behavioral training, prescription medications, or tools like anxiety vests and pheromones.
Is Benadryl Safe for Dogs?
Generally, Benadryl is well-tolerated by dogs, with minimal side effects and a low risk of overdose when administered correctly.
However, consulting with your veterinarian is crucial due to potential safety risks associated with certain health conditions or medications your dog may be taking.
Situations where Benadryl should be avoided or used with caution include:
- Cardiac conditions (cardiovascular disease)
- Some lung conditions
- Liver disease
- Seizure disorders
- Difficulties urinating
- Glaucoma
- Pregnancy
- Concurrent use of certain medications, including monoamine oxidase inhibitors and some antifungal drugs.
Side Effects of Benadryl for Dogs
At normal doses, the most common side effects in dogs are drowsiness and unsteadiness. However, excessive Benadryl can lead to:
- Increased sedation or agitation
- Severe unsteadiness
- Disorientation
- Aggression or unusual behaviors
- Slow breathing
- Vomiting
- Diarrhea
- Coma
- Seizures
Seek veterinary advice immediately if your dog exhibits any concerning symptoms after taking Benadryl.
What’s the Benadryl Dosage for Dogs?
The safest way to determine the correct dosage for your dog is to consult your veterinarian. Furthermore, be aware that some formulations are combined with other potentially harmful medications, such as Tylenol. Ensure your Benadryl tablets contain only diphenhydramine.
According to the Merck Veterinary Manual, the standard Benadryl dosage is 2–4 milligrams per kilogram of body weight, or 0.9–1.8 milligrams (mg) per pound.
A practical guideline is 1 mg of Benadryl per pound of your dog’s weight, administered two to three times daily. For instance, a 10-pound dog could receive a 10 mg dose in the morning, afternoon, and evening.
Your Dog’s Weight | Recommended Dosage | Maximum Dosage |
---|---|---|
5 pounds | 5 mg | 10 mg |
10 pounds | 10 mg | 20 mg |
20 pounds | 20 mg | 40 mg |
30 pounds | 30 mg | 60 mg |
40 pounds | 40 mg | 80 mg |
50 pounds | 50 mg | 100 mg |
75 pounds | 75 mg | 150 mg |
100 pounds | 100 mg | 200 mg |



Benadryl is available in various forms, including tablets, capsules, liquids, and children’s chewable tablets, which can complicate dosage calculations. When unsure, consult your veterinarian.
Benadryl Tablets and Capsules
Benadryl tablets typically contain 25 mg or 50 mg of diphenhydramine, suitable for 25-pound or 50-pound dogs, respectively.
For larger dogs, administer multiple tablets or capsules to reach the appropriate dose. Splitting 25 mg tablets in half allows for more precise dosing. For example, a 60-pound dog could receive one 50 mg tablet and half of a 25 mg tablet.
Children’s Chewable or Liquid Benadryl® for Dogs
Children’s chewable or liquid Benadryl are viable options for small dogs. A full chewable children’s tablet contains 12.5 mg of diphenhydramine and can be halved for dogs weighing less than 10 pounds.
Children’s liquid Benadryl, containing 2.5 mg/ml, may be easier to administer to small dogs that resist taking pills.
How Often Can You Give Your Dog Benadryl?
Benadryl can be administered to dogs every eight to 12 hours (two to three times daily).
Are There Alternatives to Giving a Dog Benadryl?
Diphenhydramine has been around for a while, and continued research has led to the development of treatments that may be more effective than Benadryl®.
Consult your veterinarian if you have questions about administering Benadryl to your dog or exploring alternative ways to maintain their health and happiness.
Benadryl can be a useful medication for dogs, but it’s crucial to understand the correct dosage, potential risks, and when alternative treatments might be more appropriate. Always consult with your veterinarian before giving your dog any medication.